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. 1983 Nov;24(5):784-6.
doi: 10.1128/AAC.24.5.784.

Pharmacokinetics and tissue penetration of ciprofloxacin

B Crump, R Wise, J Dent

Pharmacokinetics and tissue penetration of ciprofloxacin

B Crump et al. Antimicrob Agents Chemother. 1983 Nov.

Abstract

A 500-mg dose of the quinoline ciprofloxacin was administered orally to each of six healthy male volunteers, after which the concentrations of this agent in serum and blister fluid were measured. Absorption appeared to be rapid, with a mean peak level of 2.4 micrograms/ml attained 1.25 h after administration. The serum elimination half-life was 3.9 h. The agent penetrated blister fluid well, the percent penetration being 57%. Urinary recovery of ciprofloxacin was 30%.

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