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. 1983 Dec;24(6):950-1.
doi: 10.1128/AAC.24.6.950.

Pharmacokinetics of metronidazole in patients undergoing peritoneal dialysis

J G Cassey, D A Clark, P Merrick, B Jones

Pharmacokinetics of metronidazole in patients undergoing peritoneal dialysis

J G Cassey et al. Antimicrob Agents Chemother. 1983 Dec.

Abstract

After a single 500-mg intravenous dose of metronidazole, plasma and dialysate levels were measured over a 7.5-h period in five patients undergoing peritoneal dialysis for terminal renal failure. Approximately 10% of this dose was removed by dialysis during that period, and therapeutic levels were maintained in plasma. No routine adjustment in the dosage of metronidazole appears necessary in patients undergoing peritoneal dialysis.

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References

    1. Antimicrob Agents Chemother. 1977 Apr;11(4):631-7 - PubMed
    1. Antimicrob Agents Chemother. 1978 Feb;13(2):205-9 - PubMed
    1. Chemotherapy. 1981;27(6):414-5 - PubMed

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