Effect of posture on ampicillin pharmacokinetics, glomerular filtration rate and renal plasma flow in resting subjects

Abstract

Differences in drug kinetics between supine rest and ambulation have been reported, but the relative contribution of postural changes and changes in the level of physical activity has not been evaluated. Ampicillin pharmacokinetics, glomerular filtration rate (GFR) and renal plasma flow (RPF) were studied in six male volunteers at rest in the sitting and lying position with an interval of 1 week. After intravenous administration ampicillin kinetics, analyzed according to a two-compartment open model, demonstrated significant changes in drug distribution when the position was changed from lying to sitting: alpha-increased by 50%, V1 and V beta increased by 19% and 22% respectively. Ampicillin clearance, the fraction of dose recovered from urine, GFR and RPF were, however, not influenced by the change in posture. Our data on effects of posture in resting subjects suggest that previously reported differences in drug elimination and RPF between lying and ambulatory subjects are largely due to differences in the level of physical activity.