doi: 10.1016/0006-8993(83)90096-3.
A subcortico-cortical cholinergic system is affected in Parkinson's disease
- PMID: 6661617
- DOI: 10.1016/0006-8993(83)90096-3
Item in Clipboard
A subcortico-cortical cholinergic system is affected in Parkinson's disease
Brain Res.
.
Abstract
CAT activity was decreased in the frontal cortex and the substantia innominata of parkinsonian subjects, post-mortem. The decrease was greater in the frontal cortex of parkinsonians with dementia. The density of muscarinic cholinergic receptors increased in the cortex. This increase was inversely correlated with tremor. The effects on these parameters of both neuronal degeneration and anticholinergic therapy are discussed.
Similar articles
-
Muscarinic binding and choline acetyltransferase activity in Parkinsonian subjects with reference to dementia.Brain Res. 1982 Jan 28;232(1):129-39. doi: 10.1016/0006-8993(82)90615-1. Brain Res. 1982. PMID: 7055689
-
Muscarinic receptor plasticity in rats lesioned in the nucleus basalis of Meynert.Neuropharmacology. 1989 Jul;28(7):727-32. doi: 10.1016/0028-3908(89)90158-5. Neuropharmacology. 1989. PMID: 2761681
-
A post-mortem comparison of the cortical cholinergic system in Alzheimer's disease and Pick's disease.J Neurol Sci. 1983 Dec;62(1-3):211-7. doi: 10.1016/0022-510x(83)90200-9. J Neurol Sci. 1983. PMID: 6142096
-
The current status of the cortical cholinergic system in Alzheimer's disease and Parkinson's disease.Prog Brain Res. 1986;70:105-32. doi: 10.1016/s0079-6123(08)64300-9. Prog Brain Res. 1986. PMID: 3554348 Review. No abstract available.
-
The cholinergic system in Alzheimer's disease and dementia with Lewy bodies: from animal models to neuropathological data.Funct Neurol. 1997 May-Aug;12(3-4):153-7. Funct Neurol. 1997. PMID: 9218969 Review. No abstract available.
Cited by
-
Cortical vasoactive intestinal peptide in relation to dementia in Parkinson's disease.J Neurol Neurosurg Psychiatry. 1985 Aug;48(8):842-3. doi: 10.1136/jnnp.48.8.842. J Neurol Neurosurg Psychiatry. 1985. PMID: 4031938 Free PMC article. No abstract available.
-
Cholinergic Stimulation of the Adult Zebrafish Brain Induces Phosphorylation of Glycogen Synthase Kinase-3 β and Extracellular Signal-Regulated Kinase in the Telencephalon.Front Mol Neurosci. 2019 Apr 16;12:91. doi: 10.3389/fnmol.2019.00091. eCollection 2019. Front Mol Neurosci. 2019. PMID: 31040768 Free PMC article.
-
Technetium-99m hexamethylpropylene amine oxime single photon emission tomography of the brain in early Parkinson's disease: correlation with dementia and lateralization.Eur J Nucl Med. 1993 Apr;20(4):339-44. doi: 10.1007/BF00169811. Eur J Nucl Med. 1993. PMID: 8491227
-
Fractionating the Neurocognitive Mechanisms Underlying Working Memory: Independent Effects of Dopamine and Parkinson's Disease.Cereb Cortex. 2017 Dec 1;27(12):5727-5738. doi: 10.1093/cercor/bhx242. Cereb Cortex. 2017. PMID: 29040416 Free PMC article.
-
Cognitive effects of dopamine depletion in the context of diminished acetylcholine signaling capacity in mice.Dis Model Mech. 2013 Jan;6(1):171-83. doi: 10.1242/dmm.010363. Epub 2012 Aug 3. Dis Model Mech. 2013. PMID: 22864020 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous
