Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 May;53(5):417-9.
doi: 10.1136/adc.53.5.417.

Serum complement components in Henoch-Schönlein purpura

M Garcia-Fuentes, A Martin, C Chantler, D G Williams

Serum complement components in Henoch-Schönlein purpura

M Garcia-Fuentes et al. Arch Dis Child. 1978 May.

Abstract

Serum levels of C1q, C4, C3, C5, factor B, and properdin were measured in patients with Henoch-Schönlein purpura (HSP). In the cases of acute HSP, 9 of 23 (39%) had a low CH50, and 5 of 17 (30%) a low properdin; C1q, C4, and C3 levels were not depressed. In 10 cases with chronic nephritis following HSP, complement components were normal except for 2 with reduced C4 and one with low properdin. These findings confirm that complement activation occurs in HSP; the low serum levels of properdin in the acute group indicate that there is activation of the alternative pathway in these patients.

PubMed Disclaimer

References

    1. Histopathology. 1977 Mar;1(2):93-104 - PubMed
    1. Clin Exp Immunol. 1975 Aug;21(2):236-43 - PubMed
    1. Br Med J. 1977 Jul 16;2(6080):163-5 - PubMed
    1. Immunochemistry. 1976 Sep;13(9):747-52 - PubMed
    1. Lancet. 1973 Apr 21;1(7808):892-3 - PubMed

LinkOut - more resources