doi: 10.1016/0005-2736(78)90131-1.
The interaction of bee melittin with lipid bilayer membranes
- PMID: 667038
- DOI: 10.1016/0005-2736(78)90131-1
Item in Clipboard
The interaction of bee melittin with lipid bilayer membranes
Biochim Biophys Acta.
.
Abstract
The influence of melittin and the related 8-26 peptide on the stability and electrical properties of bilayer lipid membranes is reported. Melittin, unlike the 8-26 peptide, has a dramatic influence on lipid membranes, causing rupture at dilute concentrations. The circular dichroism of melittin demonstrated that under physiological conditions, in water, melittin is in extended conformation, which is enhanced in aqueous ethanol. However in 'membrane-like' conditions it is essentially alpha-helical. Secondary structure predictions were used to locate possible alpha-helical nucleation centres and a model of melittin was built according to these predictions. It is postulated that melittin causes a wedge effect in membranes.
Similar articles
-
Comparison of the conformation and orientation of alamethicin and melittin in lipid membranes.Biochemistry. 1987 Jul 14;26(14):4562-72. doi: 10.1021/bi00388a060. Biochemistry. 1987. PMID: 3663608
-
Attenuated total reflectance Fourier transform infrared studies of the interaction of melittin, two fragments of melittin, and delta-hemolysin with phosphatidylcholines.Biochemistry. 1987 Dec 15;26(25):8151-8. doi: 10.1021/bi00399a020. Biochemistry. 1987. PMID: 3442649
-
The orientation of melittin in lipid membranes. A polarized infrared spectroscopy study.Biochim Biophys Acta. 1983 Sep 7;733(2):201-9. doi: 10.1016/0005-2736(83)90523-0. Biochim Biophys Acta. 1983. PMID: 6882759
-
The actions of melittin on membranes.Biochim Biophys Acta. 1990 May 7;1031(2):143-61. doi: 10.1016/0304-4157(90)90006-x. Biochim Biophys Acta. 1990. PMID: 2187536 Review.
-
[Melittin: structure, properties, interaction with a membrane].Ukr Biokhim Zh (1978). 1986 Sep-Oct;58(5):92-103. Ukr Biokhim Zh (1978). 1986. PMID: 3535191 Review. Russian.
Cited by
-
Simulations reveal that antimicrobial BP100 induces local membrane thinning, slows lipid dynamics and favors water penetration.RSC Adv. 2022 Feb 4;12(8):4573-4588. doi: 10.1039/d1ra06267k. eCollection 2022 Feb 3. RSC Adv. 2022. PMID: 35425494 Free PMC article.
-
Distribution of distances between the tryptophan and the N-terminal residue of melittin in its complex with calmodulin, troponin C, and phospholipids.Protein Sci. 1994 Apr;3(4):628-37. doi: 10.1002/pro.5560030411. Protein Sci. 1994. PMID: 8003981 Free PMC article.
-
Comparative effects of melittin and its hydrophobic and hydrophilic fragments on bilayer organization by Raman spectroscopy.Biophys J. 1982 Jan;37(1):339-49. doi: 10.1016/S0006-3495(82)84682-1. Biophys J. 1982. PMID: 7055626 Free PMC article.
-
Amide-resolved hydrogen-deuterium exchange measurements from membrane-reconstituted polypeptides using exchange trapping and semiselective two-dimensional NMR.J Biomol NMR. 1994 Nov;4(6):879-84. doi: 10.1007/BF00398417. J Biomol NMR. 1994. PMID: 22911389
-
Melittin lysis of red cells.J Membr Biol. 1985;87(1):35-44. doi: 10.1007/BF01870697. J Membr Biol. 1985. PMID: 4057243
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
