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. 1978 Jun 22;519(1):279-84.
doi: 10.1016/0005-2787(78)90081-3.

Are the high mobility group non-histone chromosomal proteins associated with 'active' chromatin?

G H Goodwin, E W Johns

Are the high mobility group non-histone chromosomal proteins associated with 'active' chromatin?

G H Goodwin et al. Biochim Biophys Acta. .

Abstract

When 10--20% of the DNA in thymus and liver nuclei is rendered acid-soluble by DNAase I digestion, under conditions which may be expected to specifically degrade away most of the transcribed sequences, very little of the high-mobility-group non-histone proteins are released from the nuclei. Therefore, high-mobility-group proteins are probably not specifically associated with this portion of the genome.

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