Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Jul 14;37(1):37-41.
doi: 10.1007/BF01006552.

Problems in the detection of carriers of hemophilia A: the influence of stress and thrombin

U Göbel, R von Kries, H Jürgens, H von Voss

Problems in the detection of carriers of hemophilia A: the influence of stress and thrombin

U Göbel et al. Blut. .

Abstract

After exposure to stress, factor VIII coagulant activity and factor VIII antigen were determined in healthy volunteers for about 3 days. Three out of four volunteers at different time showed results resembling a carrier state. In vitro incubation of plasma with thrombin in decreasing concentrations showed increased factor VIII coagulant activity, although no fibrin clot or fibrin monomers were formed. The concentration of factor VIII antigen remained constant. The action of thrombin can explain the misclassification of known carriers.

PubMed Disclaimer

References

    1. Lancet. 1968 Dec 14;2(7581):1264-6 - PubMed
    1. J Clin Invest. 1971 Jan;50(1):244-54 - PubMed
    1. Br J Haematol. 1971 Feb;20(2):195-207 - PubMed
    1. Br J Haematol. 1975 Aug;30(4):447-56 - PubMed
    1. Anal Biochem. 1966 Apr;15(1):45-52 - PubMed