doi: 10.1126/science.66749.
Niemann-Pick disease experimental model: sphingomyelinase reduction induced by AY-9944
- PMID: 66749
- DOI: 10.1126/science.66749
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Niemann-Pick disease experimental model: sphingomyelinase reduction induced by AY-9944
Science.
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Abstract
Organs of rats treated with the drug A Y-9944 for 5 days showed a significant reduction in sphingomyelinase activity. Evidence is presented which suggests that the reduction is due to impaired enzyme synthesis.
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