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. 1977 Apr 15;196(4287):317-9.
doi: 10.1126/science.66749.

Niemann-Pick disease experimental model: sphingomyelinase reduction induced by AY-9944

N Sakuragawa, M Sakuragaw, T Kuwabara, P G Pentchev, J A Barranger, R O Brady

Niemann-Pick disease experimental model: sphingomyelinase reduction induced by AY-9944

N Sakuragawa et al. Science. .

Abstract

Organs of rats treated with the drug A Y-9944 for 5 days showed a significant reduction in sphingomyelinase activity. Evidence is presented which suggests that the reduction is due to impaired enzyme synthesis.

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