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. 1978 Jul;63(3):503-7.
doi: 10.1111/j.1476-5381.1978.tb07804.x.

Effects of gamma-aminobutyric acid on nerve terminal excitability in a slice preparation of cuneate nucleus

A G Hayes, M A Simmonds

Effects of gamma-aminobutyric acid on nerve terminal excitability in a slice preparation of cuneate nucleus

A G Hayes et al. Br J Pharmacol. 1978 Jul.

Abstract

1 Superfusion of a slice preparation of the rat cuneate nucleus with gamma-aminobutyric acid (GABA) depolarized the afferent nerve fibres and increased their excitability. However, before the depolarization had reached its peak the increased excitability reversed to a decreased excitability, an effect which outlasted the depolarization. 2 Both components of the GABA excitability response were dose-related Cl--dependent and antagonized by bicuculline. 3 Possible mechanisms underlying the sequence of excitability changes are discussed.

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References

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