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. 1977 Feb;121(2):121-6.
doi: 10.1620/tjem.121.121.

Further evidence for the involvement of base and base sequence in the antigenic determination of thermally denatured DNA

A Wakizaka, E Okuhara
Free article

Further evidence for the involvement of base and base sequence in the antigenic determination of thermally denatured DNA

A Wakizaka et al. Tohoku J Exp Med. 1977 Feb.
Free article

Abstract

The antigenic determinant of thermally denatured salmon sperm (ss) DNA was extensively investigated with a radioimmunoassay technique using the ssDNA immune system. It was demonstrated that mixed sequences of purines and pyrimidines play a key role in the antigenic determination of DNA. On the other hand, the importance of the bases in the manifestation of DNA antigenicity was demonstrated by using brominated, methylated and/or ultraviolet irradiated ssDNA preparations.

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