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Comparative Study
. 1983;3(3-4):329-37.

Pharmacokinetics of dexamethasone in children

O Richter, B Ern, D Reinhardt, B Becker
  • PMID: 6677878
Comparative Study

Pharmacokinetics of dexamethasone in children

O Richter et al. Pediatr Pharmacol (New York). 1983.

Abstract

A pharmacokinetic data analysis of plasma level data for dexamethasone obtained from children with various diseases and healthy adults was performed. A total of 33 subjects participated in the study. The results show: The pharmacokinetics of dexamethasone can be described satisfactorily within the frame of classic linear pharmacokinetic theory. The variance of important pharmacokinetic parameters is large. Therefore, if a close relationship between drug levels and therapeutic and adverse effects exists, which still has to be proved, optimal individual dosage regimens have to be calculated, guided by drug-level monitoring. When treating newborns, one should be aware that high drug levels are likely to occur, possibly necessitating a dose reduction.

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