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. 1983;1(1):89-93.
doi: 10.1007/BF00180196.

Phase II evaluation of MGBG in non-small cell carcinoma of the lung. A Southwest Oncology Group study

R B Vance, W A Knight 3rd, T T Chen, J J Costanzi, A F LoBuglio
Free article

Phase II evaluation of MGBG in non-small cell carcinoma of the lung. A Southwest Oncology Group study

R B Vance et al. Invest New Drugs. 1983.
Free article

Abstract

One hundred and eight patients with non-small cell lung cancer were treated in a Phase II trial with MGBG at a dose of 600 mg/m2 i.v. weekly. Partial responses were noted in 3/43 patients with adenocarcinoma and 1/40 with squamous cell carcinoma. No responses were noted in 24 patients with large cell carcinoma. Overall, the drug was reasonably well-tolerated. At this dosage and schedule, MGBG has no substantial antitumor activity for patients with non-small cell lung cancer.

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