doi: 10.1016/0735-6757(83)90085-2.
Tissue lactic acidosis and ischemic brain damage
- PMID: 6680617
- DOI: 10.1016/0735-6757(83)90085-2
Item in Clipboard
Tissue lactic acidosis and ischemic brain damage
Am J Emerg Med.
1983 Sep.
Abstract
Current evidence suggests that the brain has considerable potential to tolerate prolonged periods of complete ischemic anoxia. Moreover, the brain may be less damaged by complete ischemic anoxia than by severe incomplete ischemia. The accumulation of lactic acid in the brain during severe incomplete ischemia approaches three times the levels seen with complete ischemic anoxia, and this phenomenon is implicated in exacerbated biochemical and structural injury.
Similar articles
-
Glucose and the ischemic brain: a sour grape or a sweet treat?Curr Opin Clin Nutr Metab Care. 2001 Jul;4(4):287-92. doi: 10.1097/00075197-200107000-00007. Curr Opin Clin Nutr Metab Care. 2001. PMID: 11458022 Review.
-
Regional brain energy metabolism after complete versus incomplete ischemia in the rat in the absence of severe lactic acidosis.J Cereb Blood Flow Metab. 1985 Dec;5(4):490-501. doi: 10.1038/jcbfm.1985.75. J Cereb Blood Flow Metab. 1985. PMID: 4055923
-
Brain lactic acidosis and ischemic cell damage: 1. Biochemistry and neurophysiology.J Cereb Blood Flow Metab. 1981;1(3):297-311. doi: 10.1038/jcbfm.1981.34. J Cereb Blood Flow Metab. 1981. PMID: 7328145
-
Brain acidosis.Ann Emerg Med. 1985 Aug;14(8):770-6. doi: 10.1016/s0196-0644(85)80055-x. Ann Emerg Med. 1985. PMID: 3927794 Review.
-
Effect of different degrees of brain ischemia and tissue lactic acidosis on the short-term recovery of neurophysiologic and metabolic variables.Exp Neurol. 1985 Mar;87(3):458-73. doi: 10.1016/0014-4886(85)90176-1. Exp Neurol. 1985. PMID: 3972049
Cited by
-
Bedside interpretation of cerebral energy metabolism utilizing microdialysis in neurosurgical and general intensive care.Front Neurol. 2022 Aug 10;13:968288. doi: 10.3389/fneur.2022.968288. eCollection 2022. Front Neurol. 2022. PMID: 36034291 Free PMC article. Review.
-
Acidosis Maintains the Function of Brain Mitochondria in Hypoxia-Tolerant Triplefin Fish: A Strategy to Survive Acute Hypoxic Exposure?Front Physiol. 2019 Jan 18;9:1941. doi: 10.3389/fphys.2018.01941. eCollection 2018. Front Physiol. 2019. PMID: 30713504 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
