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. 1983 Mar;33(3):278-82.
doi: 10.1212/wnl.33.3.278.

Effects of 3-OM-dopa on monoamine metabolism in rat brain

J J Gervas, V Muradás, E Bazán, E G Aguado, J G de Yébenes

Effects of 3-OM-dopa on monoamine metabolism in rat brain

J J Gervas et al. Neurology. 1983 Mar.

Abstract

We studied the effects of 3-methoxy, 4-hydroxy-phenylalanine (3-OM-dopa) on monoamine turnover, L-3-4-dihydroxy-phenylalanine (L-dopa) reversal of catecholamine depletion induced by alpha-methyl-paratyrosine (alpha-MT), and the passage of L-dopa across the blood-brain barrier of the rat brain. 3-OM-dopa did not affect monoamine turnover but interfered with restoration of dopamine levels by L-dopa. In addition, systemic 3-OM-dopa decreased brain uptake of 14C-L-dopa. High 3-OM-dopa blood levels may interfere with the therapeutic response to L-dopa in parkinsonism.

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