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. 1983 Jul-Aug;67(7-8):641-6.

Action of hydrolyzed cisplatin and some analogs on microtubule protein polymerization in vitro

V Peyrot, C Briand, A Crevat, D Braguer, A M Chauvet-Monges, J C Sari
  • PMID: 6683590

Action of hydrolyzed cisplatin and some analogs on microtubule protein polymerization in vitro

V Peyrot et al. Cancer Treat Rep. 1983 Jul-Aug.

Abstract

The inhibition of tubulin microtubule polymerization by cisplatin was investigated. The interaction was monitored by turbidity measurements and electron microscopy. For a 2.5 x 10(-5) M concentration of cisplatin, the inhibition at 37 degrees C was nearly 50% after 1 hour of incubation and 80% after 2 hours. A similar but lesser effect was observed after incubation at 4 degrees C. One analog of cisplatin, sulfato-aqua(1,2)diamminocyclohexane platinum II, showed the same inhibition effect.

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