doi: 10.1126/science.6684328.
Carbocyclic arabinofuranosyladenine (cyclaradine): efficacy against genital herpes in guinea pigs
- PMID: 6684328
- DOI: 10.1126/science.6684328
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Carbocyclic arabinofuranosyladenine (cyclaradine): efficacy against genital herpes in guinea pigs
Science.
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Abstract
Carbocyclic arabinofuranosyladenine (cyclaradine), a novel nucleoside analog with such desired features as hydrolytic and enzymatic stability, adenosine deaminase resistance, and low systemic toxicity, inhibited the replication of herpes simplex virus types 1 and 2. The 5'-methoxyacetate prodrug form exhibited significant efficacy in the topical treatment of genital infections by herpes simplex virus type 2.
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