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. 1983 Sep 30;221(4618):1405-6.
doi: 10.1126/science.6684328.

Carbocyclic arabinofuranosyladenine (cyclaradine): efficacy against genital herpes in guinea pigs

R Vince, S Daluge, H Lee, W M Shannon, G Arnett, T W Schafer, T L Nagabhushan, P Reichert, H Tsai

Carbocyclic arabinofuranosyladenine (cyclaradine): efficacy against genital herpes in guinea pigs

R Vince et al. Science. .

Abstract

Carbocyclic arabinofuranosyladenine (cyclaradine), a novel nucleoside analog with such desired features as hydrolytic and enzymatic stability, adenosine deaminase resistance, and low systemic toxicity, inhibited the replication of herpes simplex virus types 1 and 2. The 5'-methoxyacetate prodrug form exhibited significant efficacy in the topical treatment of genital infections by herpes simplex virus type 2.

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