Morphine pretreatment reduces clomipramine effect in mouse forced-swimming test
- PMID: 6684579
- DOI: 10.1016/0014-2999(83)90177-2
Morphine pretreatment reduces clomipramine effect in mouse forced-swimming test
Abstract
It had previously been shown that naloxone inhibits the effect of clomipramine both in a pain test in the forced-swimming test in mice which is proposed as an antidepressant study model. Evidence is reported of a decrease in activity of clomipramine in the forced-swimming test in mice after morphine pretreatment. The hypothesis of an interaction with mu-opiate receptors is considered.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials