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. 1983 Aug 5;91(4):505-7.
doi: 10.1016/0014-2999(83)90177-2.

Morphine pretreatment reduces clomipramine effect in mouse forced-swimming test

A Eschalier, F Rigal, J L Devoize, J F Trolese, C Grillon

Morphine pretreatment reduces clomipramine effect in mouse forced-swimming test

A Eschalier et al. Eur J Pharmacol. .

Abstract

It had previously been shown that naloxone inhibits the effect of clomipramine both in a pain test in the forced-swimming test in mice which is proposed as an antidepressant study model. Evidence is reported of a decrease in activity of clomipramine in the forced-swimming test in mice after morphine pretreatment. The hypothesis of an interaction with mu-opiate receptors is considered.

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