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. 1983 Aug;79(4):993-6.
doi: 10.1111/j.1476-5381.1983.tb10546.x.

Evidence that 5-hydroxytryptamine in the forebrain is involved in naloxone-precipitated jumping in morphine-dependent rats

L Cervo, S Romandini, R Samanin

Evidence that 5-hydroxytryptamine in the forebrain is involved in naloxone-precipitated jumping in morphine-dependent rats

L Cervo et al. Br J Pharmacol. 1983 Aug.

Abstract

A withdrawal syndrome was precipitated by naloxone in morphine-dependent rats injected with 5,7-dihydroxytryptamine (5,7-DHT) in the ventromedial tegmentum (VMT) at the level of the nucleus interpeduncularis. 5,7-DHT, which markedly depleted 5-hydroxytryptamine (5-HT) in the forebrain but not in the brainstem, significantly reduced jumping in abstinent rats with no significant effect on other withdrawal signs. The effect of morphine 10 mg kg-1 on responses on the hot plate was unchanged in 5,7-DHT-treated rats. The findings suggest that 5-HT in the forebrain is selectively involved in the jumping of morphine-abstinent rats.

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References

    1. Science. 1972 Aug 18;177(4049):616-7 - PubMed
    1. J Neurochem. 1979 Jan;32(1):129-32 - PubMed
    1. Eur J Pharmacol. 1975 Dec;34(2):377-80 - PubMed
    1. Psychopharmacology (Berl). 1981;74(3):271-4 - PubMed
    1. Brain Res. 1977 Jul 8;130(1):121-34 - PubMed

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