Microcomputer based pharmacokinetic programs for calculating absorption rate

Abstract

A package of microcomputer based pharmacokinetic programs for evaluating in vivo absorption rate has been developed. The following programs are included in the package: TEXT FILE (program to create a data file which can be accessed by all pharmacokinetic programs), WN12GT (Wagner-Nelson method), LOO (modified Loo-Riegelman method), DECON (deconvolution method), and MODMOMT (method of statistical moments). All programs were tested with data obtained from standard texts or original articles. This package of programs designed to be interactive, flexible, and easily used by a novice. The modular design facilitates modification, upkeep and accommodation of new methods of calculation.