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. 1978 Jun 19;13(4):299-302.
doi: 10.1007/BF00716366.

m-Trifluoromethyl-alpha-ethylbenzhydrol: a new enzyme inducer

B Gachályi, A Káldor, S Szeberényi

m-Trifluoromethyl-alpha-ethylbenzhydrol: a new enzyme inducer

B Gachályi et al. Eur J Clin Pharmacol. .

Abstract

The enzyme inducing effect of m-trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332) has been studied in man, rat and mouse. In man, RGH-3332 decreased the half-life of antipyrine and tolbutamide and increased D-glucaric acid excretion. In rat and mouse the half-life of antipyrine was shortened. It was concluded that in all three species man, rat and mouse the liver microsomal drug metabolizing enzyme system was induced by RGH-3332. No side-effects were found on treatment with RGH-3332.

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