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. 1983;8(1):43-9.
doi: 10.1007/BF03189580.

Pharmacokinetic study of doxycycline polyphosphate+ after simultaneous ingestion of milk

M C Saux, J Mosser, H Pontagnier, B Leng

Pharmacokinetic study of doxycycline polyphosphate+ after simultaneous ingestion of milk

M C Saux et al. Eur J Drug Metab Pharmacokinet. 1983.

Abstract

Pharmacokinetic parameters of doxycycline polyphosphate were studied in healthy volunteers after oral administration of a single 200 mg dose of this antibiotic with a breakfast containing or not 200 ml of whole milk. Ingestion of milk had only mild effect upon absorption parameters of doxycycline; only a moderate increase of the lag-time was significant. Elimination parameters of doxycycline were impaired by milk; a decrease of the terminal half-life from 28 h to 15 h, and apparent decrease of the enterohepatic circulation and an increase in total body clearance from 40 to 62 ml/min. were observed.

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References

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