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Comparative Study
. 1983 Dec;26(2-3):181-8.
doi: 10.1016/0378-1119(83)90188-9.

Mapping of murine interferon-alpha genes to chromosome 4

K A Kelley, C A Kozak, F Dandoy, F Sor, D Skup, J D Windass, J DeMaeyer-Guignard, P M Pitha, E DeMaeyer
Comparative Study

Mapping of murine interferon-alpha genes to chromosome 4

K A Kelley et al. Gene. 1983 Dec.

Abstract

A cDNA library was constructed from polysomal poly(A)+RNA from Newcastle disease virus (NDV)-induced mouse C243 cells, and screened with a human interferon-alpha (HuIFN-alpha) cDNA probe. A cDNA clone for one of the murine interferon-alpha (MuIFN-alpha) genes was isolated, and sequencing analysis revealed that it was a partial copy which is almost identical to the published sequence for the MuIFN-alpha 2 gene. This partial cDNA clone represents a virus-induced message as seen by Northern blot analysis of RNA from NDV-induced C243 cells, and Southern blot analysis of DNA from BALB/c mouse revealed the presence of a multiple IFN-alpha gene family. The MuIFN-alpha genes were mapped to chromosome 4 by Southern blot analysis of hamster/mouse somatic cell hybrid DNAs.

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