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. 1983 Dec 20;11(24):8915-29.
doi: 10.1093/nar/11.24.8915.

Structural and evolutionary analysis of the two chimpanzee alpha-globin mRNAs

S A Liebhaber, K A Begley
Free PMC article

Structural and evolutionary analysis of the two chimpanzee alpha-globin mRNAs

S A Liebhaber et al. Nucleic Acids Res. .
Free PMC article

Abstract

Two distinct alpha-globin mRNAs were detected in chimpanzee reticulocyte mRNA using a primer extension assay. DNA copies of these two mRNAs were cloned in the bacterial plasmid pBR322, and their sequence was determined. The two alpha-globin mRNAs have obvious structural homology to the two human alpha-globin mRNAs, alpha 1 and alpha 2. Comparison of the two chimpanzee alpha-globin mRNAs to each other and to their corresponding human counterparts revealed evidence of a recent gene conversion in the human alpha-globin complex and a marked heterogeneity in the rate of structural divergence within the alpha-globin gene.

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