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. 1984 Jan 6;223(4631):71-4.
doi: 10.1126/science.6691137.

The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4

T Bonner, S J O'Brien, W G Nash, U R Rapp, C C Morton, P Leder

The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4

T Bonner et al. Science. .

Abstract

Two human genes that are homologous to both the murine transforming gene (oncogene) v-raf and the chicken transforming gene v-mil have been mapped by means of human-rodent somatic cell hybrids to human chromosomes previously devoid of known oncogenes. One gene, c-raf-2, which appears to be a processed pseudogene, is located on chromosome 4. The other gene, c-raf-1, which appears to be the active gene, is located on chromosome 3 and has been regionally mapped by chromosomal in situ hybridization to 3p25. This assignment correlates with specific chromosomal abnormalities associated with certain human malignancies.

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