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Case Reports
. 1984 Jan;18(1):70-1.
doi: 10.1177/106002808401800114.

Lactulose-induced hypernatremia

A A Nanji, R W Lauener
Case Reports

Lactulose-induced hypernatremia

A A Nanji et al. Drug Intell Clin Pharm. 1984 Jan.

Abstract

We describe severe hypernatremia in a patient with hepatic encephalopathy, who was treated with lactulose. Lactulose produces hypernatremia via its osmotic effect and its degradation to organic acids. We recommend that patients who receive large quantities of lactulose and who lack access to free water have their electrolytes monitored and the dose tapered as quickly as possible.

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