Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Jan;36(1):25-35.

Isolation of repetitive DNA sequences from human chromosome 21

G J Graham, T J Hall, M R Cummings

Isolation of repetitive DNA sequences from human chromosome 21

G J Graham et al. Am J Hum Genet. 1984 Jan.

Abstract

We have developed a method for the isolation of phage from the human genomic library that carry repetitive DNA sequences highly represented on specific human chromosomes. We have used this technique to select recombinants carrying inserts concentrated on chromosome 21. Five clones, representing two families of sequences, have been characterized. Members of each family show cross-homology, but the two families show no homology with each other. In all but one case, the clones do not contain members of the human Alu repeat family. Single chromosome-concentrated repetitive sequences should prove to be useful in studies of the origin, evolution, and function of repetitive DNA and in regional chromosome mapping.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nature. 1980 Mar 27;284(5754):372-4 - PubMed
    1. Proc Natl Acad Sci U S A. 1982 Dec;79(24):7804-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1980 Mar;77(3):1398-402 - PubMed
    1. Proc Natl Acad Sci U S A. 1981 Mar;78(3):1508-12 - PubMed
    1. Cold Spring Harb Symp Quant Biol. 1981;45 Pt 2:761-5 - PubMed

Publication types

LinkOut - more resources