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. 1984 Jan;36(1):25-35.

Isolation of repetitive DNA sequences from human chromosome 21

G J Graham, T J Hall, M R Cummings

Isolation of repetitive DNA sequences from human chromosome 21

G J Graham et al. Am J Hum Genet. 1984 Jan.

Abstract

We have developed a method for the isolation of phage from the human genomic library that carry repetitive DNA sequences highly represented on specific human chromosomes. We have used this technique to select recombinants carrying inserts concentrated on chromosome 21. Five clones, representing two families of sequences, have been characterized. Members of each family show cross-homology, but the two families show no homology with each other. In all but one case, the clones do not contain members of the human Alu repeat family. Single chromosome-concentrated repetitive sequences should prove to be useful in studies of the origin, evolution, and function of repetitive DNA and in regional chromosome mapping.

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References

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