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. 1984 Jan 15;217(2):419-25.
doi: 10.1042/bj2170419.

cis-Unsaturated fatty acids uncouple mitochondria and stimulate glycolysis in intact lymphocytes

P Arslan, A N Corps, T R Hesketh, J C Metcalfe, T Pozzan

cis-Unsaturated fatty acids uncouple mitochondria and stimulate glycolysis in intact lymphocytes

P Arslan et al. Biochem J. .

Abstract

In intact lymphocytes, linoleic acid acts as a typical mitochondrial uncoupler: it substantially decreases the mitochondrial membrane potential and the cellular ATP level, while stimulating oxygen consumption and glycolysis. Under these conditions the inhibition of cellular functions by linoleic acid cannot be attributed to its postulated effects on lipid domains in the plasma membrane.

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