Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Feb 27;294(1):161-5.
doi: 10.1016/0006-8993(84)91323-4.

First demonstration of highly specific and sensitive antibodies against dopamine

M Geffard, R M Buijs, P Seguela, C W Pool, M Le Moal

First demonstration of highly specific and sensitive antibodies against dopamine

M Geffard et al. Brain Res. .

Abstract

Dopamine was coupled to bovine serum albumin (BSA) with glutaraldehyde, precautions were taken in order to preserve the catechol ring. After injection of this immunogen into rabbits, anti-dopamine antibodies were obtained and tested using radioimmunochemical binding studies and adsorption to catecholamine covered sepharose beads. A good correlation was found between the results of the different test systems, allowing us to visualize dopamine specifically in glutaraldehyde-fixed rat brains.

PubMed Disclaimer

Publication types

LinkOut - more resources