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. 1978 May;20(2):412-7.
doi: 10.1128/iai.20.2.412-417.1978.

Immune reactivity of Visna virus-inoculated mice

B Svennerholm, O Strannegård, E Lycke

Immune reactivity of Visna virus-inoculated mice

B Svennerholm et al. Infect Immun. 1978 May.

Abstract

Visna virus inoculation of mice before immunization with unrelated antigens caused suppression of humoral and cell-mediated immune responses. The immunosuppressive effect was dependent on the virus dose and time of administration. The number of "background" antibody-producing spleen cells increased slightly after inoculation of Visna virus. Heat treatment of Visna virus abolished its immunosuppressive effect. Replication of Visna virus in mice seemed to be a prerequisite for its immunomodulating effect.

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