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. 1984 Feb;3(1):29-36.
doi: 10.1177/0960327184003001041.

Pharmacokinetic considerations of misonidazole in therapeutics

I Matheson, P N Plowman, A Johnston

Pharmacokinetic considerations of misonidazole in therapeutics

I Matheson et al. Hum Toxicol. 1984 Feb.

Abstract

The pharmacokinetics of misonidazole have been studies in 6 patients with special emphasis on determination of the peak concentration in plasma and saliva. Frequent sampling was performed over 4 h and a marked variation in absorption half-life (range 4-125 min) and time to peak range (0.5-6.5 h) was found. The optimal timing of irradiation is discussed. In addition to a conventional dose, one of the patients received high dose misonidazole; the pharmacokinetics are compared.

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