Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Feb;23(2):198-202.
doi: 10.1111/j.1399-3011.1984.tb02710.x.

Methylthiomethyl, a new carboxyl protecting group in peptide synthesis

A Dossena, G Palla, R Marchelli, T Lodi

Methylthiomethyl, a new carboxyl protecting group in peptide synthesis

A Dossena et al. Int J Pept Protein Res. 1984 Feb.

Abstract

N alpha-protected amino acid methylthiomethyl esters (MTM) were obtained in good yields under mild conditions using the "ButBr/Me2SO" reagent. Selective removal of the N-protecting group was achieved in HCl/anhydrous ethyl ether and the MTM ester hydrochlorides were successfully used in the synthesis of dipeptides.

PubMed Disclaimer

Publication types

LinkOut - more resources