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. 1984 Feb 14;118(3):730-5.
doi: 10.1016/0006-291x(84)91455-4.

Age-related changes in unscheduled DNA synthesis by rat hepatocytes

M M Plesko, A Richardson

Age-related changes in unscheduled DNA synthesis by rat hepatocytes

M M Plesko et al. Biochem Biophys Res Commun. .

Abstract

Ultraviolet-induced unscheduled DNA synthesis was studied as a function of age in hepatocytes isolated from 6- to 32-months-old rats. Unscheduled DNA synthesis was measured by both DNA specific activity and autoradiography. Using both procedures, a significant decline in unscheduled DNA synthesis was observed after 14 months of age.

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