Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Feb;3(1):10-3.
doi: 10.1007/BF02032807.

Clostridium difficile colitis associated with the use of antineoplastic agents

S D Miller, H J Koornhof

Clostridium difficile colitis associated with the use of antineoplastic agents

S D Miller et al. Eur J Clin Microbiol. 1984 Feb.

Abstract

Eight patients are presented in whom treatment with antineoplastic agents, in particular the folic acid antagonist methotrexate, precipitated Clostridium difficile-related diarrhoea and pseudomembranous colitis. The clinical presentation of these patients was identical to that encountered in patients developing antibiotic associated diarrhoea and colitis. Clostridium difficile-related diarrhoea and colitis should be suspected in any patient developing diarrhoea during the course of anti-neoplastic chemotherapy or within three weeks of its cessation. This complication is effectively treated with oral vancomycin.

PubMed Disclaimer

References

    1. Gastroenterology. 1962 Mar;42:295-305 - PubMed
    1. J Infect Dis. 1981 Jan;143(1):42-50 - PubMed
    1. S Afr Med J. 1983 Jun 11;63(24):936-9 - PubMed
    1. Gut. 1979 Jun;20(6):467-75 - PubMed
    1. Ann Intern Med. 1975 Dec;83(6):830-1 - PubMed