[Experimental study of the local application of silver sulfadiazine, cefsulodin and povidone-iodine in burns]

Abstract

Non-infected standardized burns and those contaminated experimentally with a constant number of organisms of a selected Pseudomonas aeruginosa strain underwent varying forms of treatment with silver sulfadiazine, cefsulodin cream and povidone iodine ointment. Wound healing was controlled by evaluating the wound area. In burns which had not been infected experimentally, healing was best without any treatment. Burns treated with cefsulodin cream showed delayed healing, though this was not significant. The most significant delay, however, was observed in wounds treated with povidone iodine. Wounds infected with Pseudomonas healed considerably better than the control group when treated prophylactically with silver sulfadiazine and cefsulodin. However, burns treated with povidone iodine again showed delayed healing.