Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Feb;47(2):201-3.
doi: 10.1136/jnnp.47.2.201.

A comparison of changes in the nucleus basalis and locus caeruleus in Alzheimer's disease

D M Mann, P O Yates, B Marcyniuk

A comparison of changes in the nucleus basalis and locus caeruleus in Alzheimer's disease

D M Mann et al. J Neurol Neurosurg Psychiatry. 1984 Feb.

Abstract

In 22 patients with Alzheimer's disease loss of neurons from the nucleus basalis of Meynert and locus caeruleus averaged 58% and 71% respectively with nucleolar volume being reduced by 30% in both. These changes were greater in those patients under 80 years of age and in such patients damage to the locus was more severe than that to the nucleus basalis. In older patients (over 80 years) changes were similar in extent in both regions.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Lancet. 1977 Mar 26;1(8013):668-71 - PubMed
    1. J Neurol Sci. 1977 Nov;34(2):247-65 - PubMed
    1. Br Med J. 1978 Nov 25;2(6150):1457-9 - PubMed
    1. Lancet. 1979 Jan 6;1(8106):11-4 - PubMed
    1. Brain Res. 1979 Aug 3;171(2):319-27 - PubMed