Cells of origin of the ventral cholinergic septohippocampal pathway undergoing compensatory collateral sprouting following fimbria-fornix transection

Abstract

The axons of the septohippocampal pathway reach the hippocampal formation via the fimbria, dorsal fornix and supracallosal striae. Complete lesions of these pathways denervate most of the hippocampal formation but a small, residual innervation occurs via a different ventral route. The cells of origin for this additional route for cholinergic innervation of the hippocampal formation have been identified in the present study with a combined technique using a fluorescent retrograde tracer and acetylcholinesterase histochemistry. These cells were localized to the diagonal band of Broca. In a subsequent experiment it was demonstrated, by destroying these cells unilaterally, that they were responsible to a large extent for the cholinergic compensatory collateral sprouting in the hippocampus that has previously been shown to develop following complete fimbria-fornix transection.