doi: 10.1093/nar/12.6.2823.
Methylation patterns of repetitive DNA sequences in germ cells of Mus musculus
- PMID: 6709503
- PMCID: PMC318708
- DOI: 10.1093/nar/12.6.2823
Item in Clipboard
Methylation patterns of repetitive DNA sequences in germ cells of Mus musculus
Nucleic Acids Res.
.
Free PMC article
Abstract
The major and the minor satellite sequences of Mus musculus were undermethylated in both sperm and oocyte DNAs relative to the amount of undermethylation observed in adult somatic tissue DNA. This hypomethylation was specific for satellite sequences in sperm DNA. Dispersed repetitive and low copy sequences show a high degree of methylation in sperm DNA; however, a dispersed repetitive sequence was undermethylated in oocyte DNA. This finding suggests a difference in the amount of total genomic DNA methylation between sperm and oocyte DNA. The methylation levels of the minor satellite sequences did not change during spermiogenesis, and were not associated with the onset of meiosis or a specific stage in sperm development.
Similar articles
-
Pattern of undermethylation of the major satellite DNA of mouse sperm.Nucleic Acids Res. 1985 Jun 11;13(11):3969-78. doi: 10.1093/nar/13.11.3969. Nucleic Acids Res. 1985. PMID: 2989780 Free PMC article.
-
Methylation of satellite sequences in mouse spermatogenic and somatic DNAs.Nucleic Acids Res. 1984 Mar 26;12(6):2807-22. doi: 10.1093/nar/12.6.2807. Nucleic Acids Res. 1984. PMID: 6324127 Free PMC article.
-
Construction of a small Mus musculus repetitive DNA library: identification of a new satellite sequence in Mus musculus.Nucleic Acids Res. 1983 Oct 25;11(20):6965-83. doi: 10.1093/nar/11.20.6965. Nucleic Acids Res. 1983. PMID: 6314268 Free PMC article.
-
Tissue specificity and organisation of CpG methylation in calf satellite DNA I.Nucleic Acids Res. 1982 Jan 22;10(2):565-76. doi: 10.1093/nar/10.2.565. Nucleic Acids Res. 1982. PMID: 6278421 Free PMC article.
-
DNA sequences and chromosome structure.J Cell Sci Suppl. 1984;1:31-41. doi: 10.1242/jcs.1984.supplement_1.3. J Cell Sci Suppl. 1984. PMID: 6397473 Review.
Cited by
-
Pathways of DNA Demethylation.Adv Exp Med Biol. 2022;1389:211-238. doi: 10.1007/978-3-031-11454-0_9. Adv Exp Med Biol. 2022. PMID: 36350512
-
DNA methylation-mediated down-regulation of DNA methyltransferase-1 (DNMT1) is coincident with, but not essential for, global hypomethylation in human placenta.J Biol Chem. 2010 Mar 26;285(13):9583-9593. doi: 10.1074/jbc.M109.064956. Epub 2010 Jan 13. J Biol Chem. 2010. PMID: 20071334 Free PMC article.
-
Human DNA sequences exhibiting gamete-specific hypomethylation.Nucleic Acids Res. 1985 Jul 11;13(13):4837-51. doi: 10.1093/nar/13.13.4837. Nucleic Acids Res. 1985. PMID: 4022775 Free PMC article.
-
Pattern of undermethylation of the major satellite DNA of mouse sperm.Nucleic Acids Res. 1985 Jun 11;13(11):3969-78. doi: 10.1093/nar/13.11.3969. Nucleic Acids Res. 1985. PMID: 2989780 Free PMC article.
-
The William Allan memorial award address: X-chromosome inactivation and the location and expression of X-linked genes.Am J Hum Genet. 1988 Jan;42(1):8-16. Am J Hum Genet. 1988. PMID: 3276178 Free PMC article. Review. No abstract available.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
