Granulocyte transfusion therapy

Abstract

Granulocyte transfusion therapy has been used as an adjunct to broad spectrum antibiotics in the management of serious infections in granulocytopenic patients. This treatment is based upon the observation that the incidence of infection is inversely related to the absolute granulocyte count in granulocytopenic patients and upon the demonstrated value of replacement therapy of other blood cell components such as platelets for thrombocytopenia. In addition, the occurrence of dramatic clinical improvement frequently noted with only small increases in granulocyte count as the marrow begins to regenerate suggests that transfusions of granulocytes should be of benefit.