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. 1984 Mar 1;218(2):615-9.
doi: 10.1042/bj2180615.

Two individuals with elliptocytic red cells apparently lack three minor erythrocyte membrane sialoglycoproteins

D J Anstee, S F Parsons, K Ridgwell, M J Tanner, A H Merry, E E Thomson, P A Judson, P Johnson, S Bates, I D Fraser

Two individuals with elliptocytic red cells apparently lack three minor erythrocyte membrane sialoglycoproteins

D J Anstee et al. Biochem J. .

Abstract

We have studied the erythrocytes of two individuals (P. L. and K. W.) who lack the Gerbich (Ge) blood-group antigen. The erythrocytes of P. L. and K. W. were not reactive with two monoclonal antibodies (NBTS/BRIC 4 and NBTS/BRIC 10) which reacted with normal erythrocytes. The membranes of P. L. and K. W. erythrocytes appeared to lack three minor sialoglycoproteins (beta, beta 1 and gamma). These three minor sialoglycoproteins were found to be associated with the cytoskeletons of normal erythrocytes. Approx. 10% of the erythrocytes of P. L. and K. W. were frankly elliptocytic. We suggest that one or more of the minor sialoglycoproteins may play a part in maintaining the discoid shape of the human erythrocyte.

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