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. 1978 Aug;67(8):1178-9.
doi: 10.1002/jps.2600670844.

Effect of changes in intercompartment rate constants on drug removal during hemoperfusion

T P Gibson, A J Atkinson Jr

Effect of changes in intercompartment rate constants on drug removal during hemoperfusion

T P Gibson et al. J Pharm Sci. 1978 Aug.

Abstract

A computer simulation of the effect of changing intercompartment clearance rates on drug removal during hemoperfusion was undertaken. As intercompartment clearance slowed, the fall in plasma levels increased and postperfusion rebound increased, but the total drug removed decreased.

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