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. 1984 Jan-Feb;29(1):158-9.

[Effect of phosphodiesterase inhibitors on the membrane potential and respiration of mitochondria]

[Article in Russian]
E A Liberman, L M Tsofina
  • PMID: 6713004

[Effect of phosphodiesterase inhibitors on the membrane potential and respiration of mitochondria]

[Article in Russian]
E A Liberman et al. Biofizika. 1984 Jan-Feb.

Abstract

Effect of papaverine, 3-isobutyl-1-methylxanthine and SQ-20009 was studied. It was shown that papaverine (50 microM) had rotenone--like action on isolated rat liver mitochondria decreasing their membrane potential and blocking respiration upon beta-oxybutyrate oxidation. Papaverine did not practically influence the membrane potential and oxygen consumption upon succinate oxidation. SQ-20009 effect was much less than that of papaverine. 3-isobutyl-1-methylxanthine (50-200 microM) was uneffective at all.

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