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. 1978 May:278:461-9.
doi: 10.1113/jphysiol.1978.sp012317.

A transient release of potassium mediated by the action of substance P on rat parotid slices

Z Y Friedman, Z Selinger

A transient release of potassium mediated by the action of substance P on rat parotid slices

Z Y Friedman et al. J Physiol. 1978 May.

Abstract

Substance P (a peptide of eleven amino acids) caused a Ca-dependent release of K+ from rat parotid slices. The response to substance P differed from the alpha-adrenergic and the cholinergic responses in that it was transient, of smaller extent, and was not inhibited by phentolamine and atropine. Substance P caused little, if any, amylase secretion. Successive additions of the peptide to the slice system maintained the effect of C+ release indicating that the transient response to a single addition of the peptide was due to inactivation of substance P and not due to a decline in the response of the tissue.

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References

    1. Cold Spring Harb Symp Quant Biol. 1976;40:135-43 - PubMed
    1. Methods Enzymol. 1975;39:461-6 - PubMed
    1. J Cyclic Nucleotide Res. 1975;1(4):181-92 - PubMed
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