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. 1984 Jan;365(1):83-94.
doi: 10.1515/bchm2.1984.365.1.83.

[Synthesis of peptides with gastrinlike activity. Studies on the structure-activity relationship of the natural hormone human little gastrin I]

[Article in German]
W Göhring, L Moroder, G Borin, A Lobbia, J P Bali, E Wünsch

[Synthesis of peptides with gastrinlike activity. Studies on the structure-activity relationship of the natural hormone human little gastrin I]

[Article in German]
W Göhring et al. Hoppe Seylers Z Physiol Chem. 1984 Jan.

Abstract

To identify the role of the block of glutamic acid residues characteristic for the gastrin molecule, a series of shortened peptides related to the human little-gastrin-I sequence were synthesized. The biological activities of these gastrin peptides strongly suggest in the pentaglutamic acid sequence a specific information for a pronounced amplification of the hormonal activity.

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