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. 1984 Mar 9:306:291-301.
doi: 10.1016/s0378-4347(00)80891-9.

High-performance liquid chromatographic method for the determination of N-methylated metabolites of nicotine

K C Cundy, P A Crooks

High-performance liquid chromatographic method for the determination of N-methylated metabolites of nicotine

K C Cundy et al. J Chromatogr. .

Abstract

An analytical method has been developed, using cation-exchange high-performance liquid chromatography, for the analysis of N-methylated metabolites of nicotine. This method has been used to detect and quantitate seven potential in vivo urinary metabolites of [2'-14C]-nicotine, including four methylated nicotine derivatives, in the guinea pig.

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