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. 1978 Jun 20;11(2):87-93.
doi: 10.1007/BF01733884.

Formation of the imidazolides of dinucleotides under potentially prebiotic conditions

H L Sleeper, R Lohrmann, L E Orgel

Formation of the imidazolides of dinucleotides under potentially prebiotic conditions

H L Sleeper et al. J Mol Evol. .

Abstract

Imidazolides of dinucleotides such as ImpApA can be formed from the corresponding dinucleotides in a two-stage process, which gives up to 15% yields under potentially prebiotic conditions. First a solution of the dinucleotide and sodium trimetaphosphate is dried out at constant temperature and humidity. This produces polyphosphates such pnApA in excellent yield (greater than or equal to 80%). The products are dissolved in water, imidazole is added, and the solution is dried out again. This yields the 5'--phosphorimidazolides.

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References

    1. J Mol Evol. 1977 Nov 25;10(2):137-54 - PubMed
    1. J Mol Evol. 1977 Aug 5;9(4):323-8 - PubMed
    1. J Mol Evol. 1974;3(4):323-30 - PubMed
    1. Biochim Biophys Acta. 1972 Nov 9;281(4):477-80 - PubMed
    1. J Mol Evol. 1975 Dec 29;6(4):237-52 - PubMed

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