doi: 10.1084/jem.145.4.1077.
Immune mechanisms in leukemia role of the Ia antigens
- PMID: 67166
- PMCID: PMC2180632
- DOI: 10.1084/jem.145.4.1077
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Immune mechanisms in leukemia role of the Ia antigens
J Exp Med.
.
Abstract
We have shown that the selective removal of cells possessing Ia determinants coded by the I-A, I-B, and I-J regions of the H-2 gene complex completely abrogates the protective capacity of nylon-wool-purified T lymphocytes against leukemic challenge. This suggests that the Ia antigen bearing T cells play an important role in tumor immunity.
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